Liverpool will have to make it do without Trent Alexander-Arnold, Luis Diaz and Joel Matip who sustained injuries during a massive clash with Arsenal in London this past weekend.
However, the Reds will receive a major boost with the return of Andy Robertson while Curtis Jones, Naby Keita and Alex Oxlade-Chamberlain are not yet ready to return.
The Merseyside outfit beat Rangers 2-1 in the first round of the group stages last week at Anfield.
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“That is not great, but it is the situation and we have to deal with it and we will,” Klopp said of the setbacks for Alexander-Arnold, Diaz and Matip,” Liverpool coach Jurgen Klopp told Liverpool.com.
“Robbo is in the squad; Curtis not, Ox not, Naby not. That’s it. It’s important the boys [are] coming back but it is not that you are back, train twice with the team and then here we go. It’s not like this.”
Liverpool will be aiming for a return to winning ways following a hurting 3-2 loss to the Gunners in the Premier League on Sunday.
“This is a tough situation, but it’s a challenge and we face always challenges and we go for it,” added Klopp.
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“I’m sorry for our people, they expected after last season we go again, fly again and compete with everything. Now it’s not the case. I cannot promise we will fly [tonight] but I can promise we will fight, definitely.
“Until somebody tells us the fight is over, that’s all we can promise. Yes, it didn’t become easier since Sunday because of the injuries but the team I saw [on Tuesday] in training I liked a lot. So, let’s give it a go.”